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Preclinical studies investigating the effects of AMPK have suggest it may have the following applications:

AMPK may boost metabolism & improve energy levels

AMPK boosts metabolism by acting as the body’s energy regulator, ensuring cells efficiently produce and use energy. When activated, AMPK stimulates processes that generate energy, such as glucose uptake and fatty acid oxidation, while suppressing energy-consuming activities like fat and protein synthesis. This shift prioritizes breaking down stored energy sources, like fats, to meet the body’s immediate energy demands. Additionally, AMPK enhances mitochondrial function, increasing the cell’s capacity to produce energy over time. By optimizing energy balance and promoting efficient fuel usage, AMPK plays a key role in accelerating metabolism, supporting weight management, and improving overall energy levels [2].

AMPK could promote fat burning

AMPK promotes fat burning by activating pathways that break down stored fats and inhibit fat storage processes. When energy levels are low, AMPK triggers the breakdown of triglycerides into free fatty acids, which are then oxidized in the mitochondria to produce energy. Simultaneously, AMPK suppresses lipogenesis, the process of creating new fat, by inhibiting enzymes involved in fat synthesis. It also enhances the activity of enzymes responsible for fatty acid oxidation, ensuring fats are efficiently used as a fuel source. This dual action of increasing fat breakdown and reducing fat storage makes AMPK a key player in promoting fat burning [4].

AMPK supports cellular health and reduces oxidative stress

AMPK supports cellular health by enhancing energy efficiency and promoting processes that maintain cellular function. It stimulates mitochondrial biogenesis, improving the cell’s ability to produce energy and sustain vital activities. Additionally, AMPK activates autophagy, a process that removes damaged cellular components, preventing the accumulation of harmful debris. By reducing energy-demanding processes like protein and lipid synthesis, AMPK conserves resources for essential cellular repair. It also reduces oxidative stress by lowering the production of reactive oxygen species (ROS) and enhancing antioxidant defences. This combination of energy regulation, repair mechanisms, and stress reduction helps protect cells from damage and supports overall cellular health [5].

AMPK may reduce blood sugar 

AMPK reduces blood sugar by enhancing the body’s ability to utilize glucose effectively. When activated, AMPK increases glucose uptake in muscle cells by promoting the translocation of glucose transporter proteins (GLUT4) to the cell surface, allowing more glucose to enter the cells from the bloodstream. Additionally, AMPK inhibits glucose production in the liver by suppressing gluconeogenesis, the process of creating glucose from non-carbohydrate sources. By simultaneously increasing glucose utilization and reducing its production, AMPK helps lower blood sugar levels, improve insulin sensitivity, and maintain overall glucose balance, making it a critical player in managing blood sugar and metabolic health [6].

AMPK promotes anti-aging

AMPK may support anti-aging by promoting cellular processes that enhance longevity and reduce age-related damage. It activates autophagy, a mechanism that clears out damaged cellular components, preventing the build up of harmful debris that accelerates aging. AMPK also boosts mitochondrial biogenesis, improving energy production and reducing oxidative stress, which are key factors in cellular aging. Additionally, it lowers inflammation and supports metabolic balance, both of which are linked to healthier aging [7]. By optimizing energy efficiency, protecting cells from damage, and maintaining overall cellular health, AMPK plays a vital role in potentially slowing the aging process and promoting a longer, healthier lifespan.

AMPK may improve cardiovascular health

AMPK may improve cardiovascular health by supporting processes that protect the heart and blood vessels. It enhances endothelial function by promoting nitric oxide production, which helps relax blood vessels and improve blood flow. AMPK also reduces inflammation and oxidative stress, both of which contribute to arterial damage and cardiovascular disease. Additionally, it inhibits the build up of fatty deposits in arteries by reducing lipid synthesis and promoting fat oxidation. By improving energy efficiency in heart cells and protecting against stressors, AMPK helps maintain healthy blood pressure, prevent atherosclerosis, and support overall cardiovascular function, reducing the risk of heart-related conditions [8].