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What is PTD-DBM?

PTD-DBM is a synthetic cell-penetrating peptide designed to modulate the Wnt/β-catenin signalling pathway, a vital mechanism in hair follicle development, tissue regeneration, and cellular repair. By inhibiting the interaction between the protein CXXC5 and Dishevelled (Dvl), PTD-DBM reactivates this pathway, promoting processes such as cellular proliferation and differentiation.

This peptide has garnered attention for its potential applications in combating hair loss, as it stimulates hair follicle growth and improves scalp health [1]. Beyond hair treatment, PTD-DBM supports tissue repair and enhances cellular delivery of biomolecules, making it a valuable innovation in therapeutic practices and advanced molecular biology research [2].

Molecular Formula: C124H22N61O28S2

Sequence: RRRRRRRRGGGGRKTGHQ ICKFRKC

Molecular Weight: 3082.65 g/mol

View the PharmaLabGlobal PTD-DBM HPLC Certificate here.

Potential Benefits of PTD-DBM Turkey

Buy PTD-DBM Peptide Vial here – Available in 1mg vials for research purposes.

Mechanism of Action of PTD-DBM Turkey

PTD-DBM peptide operates by modulating the Wnt/β-catenin signaling pathway, a critical regulator of cellular development, tissue regeneration, and hair follicle function. This pathway is often disrupted by CXXC5, a protein that acts as a negative regulator [1].

PTD-DBM works by inhibiting the interaction between CXXC5 and Dishevelled (Dvl), an upstream component of Wnt/β-catenin signaling. By blocking this interaction, PTD-DBM reactivates the pathway, promoting processes like cellular proliferation, differentiation, and regeneration.

This targeted modulation of cellular pathways enables PTD-DBM to have widespread applications. Therapeutically, it fosters tissue repair and regeneration, making it a potential solution for conditions like chronic wounds or degenerative diseases [3].

Additionally, its ability to facilitate cellular delivery of biomolecules makes it valuable in research, aiding advancements in gene expression studies and protein functionality. Its precision, combined with minimal off-target effects, places PTD-DBM as a promising tool in both clinical and molecular biology domains.

Buy PTD-DBM Nasal Spray for research use. Peptide nasal sprays are convenient and painless way of studying the potential benefits of peptides.

Buy PTD-DBM Turkey Peptide from PharmaLabGlobal

Potential Applications of PTD-DBM Turkey

PTD-DBM is a novel peptide which is under investigation for the following applications:

Promotes follicle health and hair growth

PTD-DBM enhances follicle health and promotes hair growth by targeting the Wnt/β-catenin signaling pathway, a key player in hair follicle development and regeneration. This peptide inhibits the interaction between CXXC5, a negative regulator, and Dishevelled (Dvl), an essential component of this pathway. By reactivating Wnt/β-catenin signaling, PTD-DBM stimulates the proliferation and differentiation of hair follicle cells, fostering the formation of new follicles and the rejuvenation of existing ones [1]. Additionally, it improves scalp health by encouraging cellular repair and reducing follicular stress. These combined effects make PTD-DBM a powerful tool in addressing hair loss and promoting robust hair growth [4].

Modulates cellular signalling

PTD-DBM is a cell-penetrating peptide that facilitates targeted delivery and modulation of key cellular signaling processes, including the Wnt/β-catenin pathway. This pathway plays a central role in biological functions such as tissue regeneration, cellular repair, and homeostasis. PTD-DBM works by blocking the interaction between CXXC5, a negative regulator, and Dishevelled (Dvl), restoring the pathway’s activity [5]. By reactivating Wnt/β-catenin signaling, PTD-DBM stimulates cell proliferation, differentiation, and regeneration. Its precision reduces off-target effects, making it an effective tool for therapeutic applications. From promoting healing in damaged tissues to advancing cellular research, PTD-DBM underpins advancements in medicine and molecular biology.

Enhances tissue repair and regeneration

PTD-DBM plays a significant role in enhancing wound healing and tissue regeneration through its modulation of the Wnt/β-catenin signaling pathway. This pathway is crucial for cellular repair, proliferation, and the restoration of tissue integrity. PTD-DBM works by inhibiting the interaction between the negative regulator CXXC5 and Dishevelled (Dvl), reactivating the Wnt/β-catenin pathway [5]. This reactivation promotes the proliferation of fibroblasts, keratinocytes, and other essential cell types involved in tissue repair. Additionally, further studies suggests it encourages cellular differentiation and extracellular matrix production, accelerating wound closure and healing. By targeting this pathway, PTD-DBM also helps reduce oxidative stress and inflammation, further supporting tissue recovery. Its precise mechanism ensures localized action, minimizing undesired effects [6]. This makes PTD-DBM a valuable therapeutic tool in regenerative medicine, particularly for conditions requiring enhanced cellular repair and tissue restoration.

Supports genetic research

PTD-DBM cell-penetrating properties enable precise delivery of therapeutic agents, DNA, RNA, or proteins into cells, making it a versatile tool for studying gene expression. PTD-DBM’s specificity minimizes off-target effects, facilitating accurate exploration of cellular functions and genetic mechanisms [7]. These capabilities make it indispensable for advancing molecular biology research, understanding complex genetic pathways, and even testing new therapeutic approaches in experimental models.

Buy PTD-DBM Pre-Mixed Peptide Pen. Pen kits and pre-mixed refill cartridges supplied by PharmaLabGlobal. All Peptide products are intended for research professionals.

PTD-DBM Nasal Spray Peptide Turkey 30ml from PharmaLabGlobal

Can PTD-DBM treat androgenetic alopecia?

Yes, PTD-DBM has shown potential in treating androgenetic alopecia (pattern baldness).

 

Frequently Asked Questions about PTD-DBM

Is PTD-DBM known as a hair growth peptide Turkey?

Yes, PTD-DBM is recognized as a peptide associated with hair growth. It works by targeting the Wnt/β-catenin signaling pathway, which is crucial for hair follicle regeneration. This powerful mechanisms action promotes the formation of new hair follicles and prevents hair loss. Studies have shown that combining PTD-DBM with valproic acid serum, a Wnt/β-catenin pathway activator, enhances its effectiveness in stimulating hair regrowth giving visible results and thick hair.

Is PTD-DBM approved to treat hair loss?

PTD-DBM is not currently approved by regulatory bodies like the FDA for the treatment of hair loss. While it has shown promise in preclinical studies for promoting hair regrowth and follicle development, it remains in the research and development phase.

What are the side effects of PTD-DBM?

As PTD-DBM is applied topically, there may be a risk of mild skin irritation or redness at the application site, similar to other topical treatments.

Buy PTD-DBM GHK-Cu Peptide Combo Turkey

Combining PTD-DBM and GHK-Cu peptides unlocks promising benefits by harnessing their complementary roles in cellular repair, tissue regeneration, and hair growth. PTD-DBM modulates the Wnt/β-catenin signalling pathway, promoting cellular proliferation and differentiation, while GHK-Cu rejuvenates skin, reduces inflammation, and stimulates collagen and elastin production.

Together, they create a synergistic effect, enhancing tissue recovery, improving skin elasticity, and accelerating wound healing. This combination also optimizes scalp health, fortifies hair follicles, and stimulates robust hair growth, addressing hair loss more effectively. Their harmony in modulating cellular signaling pathways positions them as valuable tools in regenerative medicine, skincare, and advanced therapeutic interventions.

Buy PTD-DBM GHK-Cu Peptide Combo from Pharma Lab Global website.

Scientific Research

[1] Choi BY. Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss. Int J Mol Sci. 2020 Jul 12;21(14):4915.

[2] Asoh S, Ohta S. PTD-mediated delivery of anti-cell death proteins/peptides and therapeutic enzymes. Adv Drug Deliv Rev. 2008 Mar 1;60(4-5):499-516.

[3] Gumede, D.B., Abrahamse, H. & Houreld, N.N. Targeting Wnt/β-catenin signaling and its interplay with TGF-β and Notch signaling pathways for the treatment of chronic wounds. Cell Commun Signal 22, 244 (2024)

[4] Ryu YC, Park J, Kim YR, Choi S, Kim GU, Kim E, Hwang Y, Kim H, Han G, Lee SH, Choi KY. CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2. Cells. 2023 Feb 9;12(4):555.

[5] Lee SH, Kim MY, Kim HY, Lee YM, Kim H, Nam KA, Roh MR, Min do S, Chung KY, Choi KY. The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing. J Exp Med. 2015 Jun 29;212(7):1061-80.

[6] Tsaryk R, Peters K, Barth S, Unger RE, Scharnweber D, Kirkpatrick CJ. The role of oxidative stress in pro-inflammatory activation of human endothelial cells on Ti6Al4V alloy. Biomaterials. 2013 Nov;34(33):8075-85.

[7] Soung-Hoon Lee, Seol Hwa Seo, Dong-Hwan Lee, Long-Quan Pi, Won-Soo Lee, Kang-Yell Choi, Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis, Journal of Investigative Dermatology, Volume 137, Issue 11, 2017, Pages 2260-2269,

Further Reading:

PTD-DBM Peptide: A Promising Solution for Hair Loss Treatment

The blog explores the potential of PTD-DBM as a promising peptide for addressing hair loss. It highlights how PTD-DBM targets the Wnt/β-catenin signaling pathway by inhibiting the CXXC5 protein, which suppresses hair follicle activity. By reactivating dormant follicles, PTD-DBM shows potential for stimulating hair regrowth. The article also discusses the complementary role of GHK-Cu, another peptide that enhances scalp health and supports hair follicle growth through angiogenesis and tissue repair. While both peptides are still in the research phase, their ability to address the molecular causes of hair loss offers hope for future, more effective treatments.

What Causes Baldness?

This article dives into the causes and treatments of baldness, focusing on factors like genetics, hormonal changes, stress, and health conditions that contribute to hair loss. It highlights emerging research on peptides such as PTD-DBM and GHK-Cu, which show promise in promoting hair regrowth and supporting scalp health, albeit still in experimental stages. The post concludes with practical advice for managing hair health, including maintaining a nutrient-rich diet, reducing stress, and consulting a dermatologist to slow or prevent baldness.

Unveiling the Potency of PTD-DBM and GHK-Cu Peptides in Revolutionizing Hair Regrowth

Delve into the synergistic potential of PTD-DBM and GHK-Cu peptides in promoting hair regrowth. PTD-DBM targets dormant hair follicles by modulating cellular regeneration, while GHK-Cu enhances blood circulation, collagen production, and antioxidant defense, creating an optimal environment for hair growth. Together, these peptides stimulate hair follicles, improve hair strength, and protect against oxidative stress. The article highlights their scientific basis, emphasizing their role in addressing the root causes of hair loss, such as hormonal imbalances and follicle dormancy. This combination represents a promising, research-backed approach to combating hair loss and advancing hair care solutions.

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